Per- and polyfluoroalkyl chemicals (PFAS) may promote cancer metastasis, according to a study by researchers at the Yale School of Public Health
Researchers immersed 2 types of colorectal cancer cells in a PFAS solution for up to 7 days; metabolic changes signaling cancer metastasis were observed, along with increased cell motility
Not only was the cells’ migration ability boosted, but they had a tendency to spread and penetrate membranes
PFAS may lead to altered gene expression and epigenetic changes that in turn cause inflammation, endocrine disruption and changes in metabolism and cell signaling that promote carcinogenesis
Other research shows exposure to PFAS may worsen the prognosis of patients with colorectal cancer
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